Antianaphylactic agents. 1. 2-(Acylamino)oxazoles
- 1 April 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (4), 412-417
- https://doi.org/10.1021/jm00190a011
Abstract
The synthesis and biological properties of 35 2-(acylamino)oxazoles were described. The majority of the compounds inhibited the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. Several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.This publication has 6 references indexed in Scilit:
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- The release of histamine and formation of a slow‐reacting substance (SRS‐A) during anaphylactic shockThe Journal of Physiology, 1960
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