The anthelmintic efficacy of mebendazole against adultFasciola hepaticaand a concurrent mixed nematode infection in sheep

Abstract

Extract Delak et al. (1965) Delak, M. , Mijatovic, I. and Mikacic, D. 1965. Simultana primijina thiabendazola i heksaklorafena μ suzbijanju dikrocelioze i fascioloze μ ovaca. Vet. Ark., 35(7/8): 197–203. [Google Scholar] reported that thiabendazole in combination with hexachlorophene (163 to 254 mg/kg thiabendazole; 16.3 to 25.4 mg/kg hexachlorophene) was effective in removing adult Fasciola hepatica from infected sheep. This would appear to be the only record of a benzimidazole derivative; having significant anthelmintic activity against F. hepatica. It is interesting to note, however, that a related trematode, Dicrocoelium dendriticum (the lancet fluke), can be eliminated from infected sheep by thiabendazole alone, at a dose rate of 500 mg/kg ( Guilhon, 1965 Guilhon, J. 1965. Traitment de la dicrocoeliose ovine par le thiazolylbenzimidazole. Bull. Acad. Vet. France, 38: 155–163. [Google Scholar] ).