Partial Protection of Mice by Human Gamma-Globulin Against Staphylococcus aureus on Subcutaneous Sutures.

Abstract

The technic of subcutaneous implantation of sutures infected with S. aureus was used to assay protection of mice by pooled human gamma globulin. The mice which received 1 ml each of gamma globulin in divided doses showed 30 to 35% fewer purulent skin lesions than controls. The infected sutures, however, were not freed of viable staphylococci. This model system is regarded as being sufficiently satisfactory to warrant its continued use in experiments toward elucidation of critical factors in pathogenesis and protection.