Streptozotocin: inherent but not expressed skin sensitizing activity
- 1 September 1995
- journal article
- Published by Wiley in Contact Dermatitis
- Vol. 33 (3), 165-167
- https://doi.org/10.1111/j.1600-0536.1995.tb00538.x
Abstract
We have shown previously that the alkylating agent streptozotocin (STZ) fails to induce responses in the murine local lymph node assay, a predictive test for contact sensitizing potential. In the present study we demonstrate that this same compound when injected intradermally into the ears of mice provokes a dose‐dependent induction of draining lymph node cell proliferation. These data indicate that the intrinsic immunogenicity of STZ is not displayed in the local lymph node assay under conditions of conventional topical exposure, secondary to a failure to cross the lipophilic stratum corneum in sufficient, quantities. This finding has implications for the discernment of structure‐activity relationships in contact sensitization.Keywords
This publication has 6 references indexed in Scilit:
- Development of an expert system rulebase for identifying contact allergensToxicology in Vitro, 1994
- Morphology of popliteal lymph node responses in brown‐norway ratsJournal of Toxicology and Environmental Health, 1994
- Mechanistic relationship among mutagenicity, skin sensitization, and skin carcinogenicity.Environmental Health Perspectives, 1993
- Activation of CD4+ and CD8+ lymphocyte subsets by streptozotocin in murine popliteal lymph node (PLN) testJournal of Autoimmunity, 1992
- The murine local lymph node assay: A commentary on collaborative studies and new directionsFood and Chemical Toxicology, 1992
- A murine local lymph node assay for the identification of contact allergensArchives of Toxicology, 1989