Histological Studies on the Influence of Thorotrast on the Intrahepatic Distribution of T-1824

Abstract

Histologic examination of the distribution of T-1824 in normal rats and in rats pretreated with Thorotrast, indicate that von Kupffer cells of the liver remove dye-labeled protein from the circulation. The von Kupffer cells of the liver first take up the colloidal Thorotrast, become swollen, tend to occlude sinusoidal circulation and take up dye-labeled protein. This then was confirmed by C injection studies. Forty-eight hours after Thorotrast injection, the initial swelling of the reticulo-endothelial cells in the liver has disappeared and dye removed rate has returned to contract levels.