AN EFFICIENT METHOD FOR THE SYNTHESIS OF PEPTIDES BY THE USE OF PHENYLPHOSPHONIC ESTERS
- 5 November 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 8 (11), 1305-1308
- https://doi.org/10.1246/cl.1979.1305
Abstract
Treatment of the tetrabutylammonium salt of N-benzoyl-L-leucine and glycine ethyl ester with bis(o- or p-nitrophenyl) phenylphosphonate in DMF resulted in the formation of the corresponding dipeptide in excellent yield with high optical purity. Similarly, racemization-free Z-L-Phe-Gly-OEt was prepared in high yield.Keywords
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