Effects of GABAergic Drugs In Vivo on High-Affinity Choline Uptake In Vitro in Mouse Hippocampal Synaptosomes
- 1 December 1986
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 47 (6), 1916-1918
- https://doi.org/10.1111/j.1471-4159.1986.tb13107.x
Abstract
The effects of several .gamma.-aminobutyric acid (GABA)-ergic drugs on sodium-dependent high-affinity choline uptake (HACU) were investigated in the hippocampus. HACU was measured in vitro administration of the drug to mice. HACU was inhibited by those drugs that enhance GABA transmission. The convulsant 3-mercaptopropionic acid, which decreases GABA levels, stimulated HACU. From these results and previous findings, it appears that GABA mediates a tonic inhibitor effect on the septal-hippocampal cholinergic system.Keywords
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