An investigation of the cause of renal hypertrophy in rats fed on a high protein diet

Abstract

The increase in kidney wt. of rats fed with a number of proteins and protein derivatives was studied. Gelatin tended to produce a more marked increase in kidney wt. than either caseinogen or liver. Glycine, glutamic acid and gluten produced an increase which was roughly proportional to the additional N consumed. It is considered likely that the hypertrophy is associated with some stage in the intermediary metabolism of pro-tein[long dash]probably deamination by the kidney.