FURTHER OBSERVATIONS CONCERNING EFFECT OF ADRENALECTOMY ON ALLOXAN DIABETES: PAIRED FEEDING EXPERIMENTS

Abstract

Rats of the Long-Evans strain made diabetic with alloxan were adrenalectomized and studied under paired feeding conditions. In the present expt., the amelioration of diabetes which occurs following adrenalectomy was found to be associated with the lowered food intake, with resulting decreases in urine and blood sugar, rather than to adrenalectomy per se. Following a 24 hr. fast, however, the carbohydrate stores of the adrenalectomized diabetic animals were largely depleted, in fact, the liver glycogen levels of these animals averaged only 15% of that found in the control diabetics.