N‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Increases Acetylcholine and Decreases Dopamine in Mouse Striatum: Both Responses Are Blocked by Anticholinergic Drugs
- 1 December 1985
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 45 (6), 1957-1959
- https://doi.org/10.1111/j.1471-4159.1985.tb10558.x
Abstract
The neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces neuropathology and clinical symptoms that resemble Parkinsonism in primates and humans. In mice it induces a long-lasting depletion of neostriatal 3,4-dihydroxyphenylethylamine (dopamine) content. Using the mouse, we found that MPTP induces a fall of dopamine and a rise of acetylcholine in the neostriatum. Both responses to MPTP can be blocked by prior treatment with atropine or trihexyphenidyl.Keywords
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