Research Questions and Priorities for Tuberculosis: A Survey of Published Systematic Reviews and Meta-Analyses
Open Access
- 27 July 2012
- journal article
- review article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (7), e42479
- https://doi.org/10.1371/journal.pone.0042479
Abstract
Systematic reviews are increasingly informing policies in tuberculosis (TB) care and control. They may also be a source of questions for future research. As part of the process of developing the International Roadmap for TB Research, we did a systematic review of published systematic reviews on TB, to identify research priorities that are most frequently suggested in reviews. We searched EMBASE, MEDLINE, Web of Science, and the Cochrane Library for systematic reviews and meta-analyses on any aspect of TB published between 2005 and 2010. One reviewer extracted data and a second reviewer independently extracted data from a random subset of included studies. In total, 137 systematic reviews, with 141 research questions, were included in this review. We used the UK Health Research Classification System (HRCS) to help us classify the research questions and priorities. The three most common research topics were in the area of detection, screening and diagnosis of TB (32.6%), development and evaluation of treatments and therapeutic interventions (23.4%), and TB aetiology and risk factors (19.9%). The research priorities determined were mainly focused on the discovery and evaluation of bacteriological TB tests and drug-resistant TB tests and immunological tests. Other important topics of future research were genetic susceptibility linked to TB and disease determinants attributed to HIV/TB. Evaluation of drug treatments for TB, drug-resistant TB and HIV/TB were also frequently proposed research topics. Systematic reviews are a good source of key research priorities. Findings from our survey have informed the development of the International Roadmap for TB Research by the TB Research Movement.Keywords
This publication has 142 references indexed in Scilit:
- Priorities for tuberculosis research: a systematic reviewThe Lancet Infectious Diseases, 2010
- Does Bleach Processing Increase the Accuracy of Sputum Smear Microscopy for Diagnosing Pulmonary Tuberculosis?Journal of Clinical Microbiology, 2010
- Clinical and Toxicodynamic Evidence that High-Dose Pyrazinamide Is Not More Hepatotoxic than the Low Doses Currently UsedAntimicrobial Agents and Chemotherapy, 2010
- Sputum monitoring during tuberculosis treatment for predicting outcome: systematic review and meta-analysisThe Lancet Infectious Diseases, 2010
- Yield of HIV-associated tuberculosis during intensified case finding in resource-limited settings: a systematic review and meta-analysisThe Lancet Infectious Diseases, 2010
- Diagnostic Accuracy of In-House PCR for Pulmonary Tuberculosis in Smear-Positive Patients: Meta-Analysis and MetaregressionJournal of Clinical Microbiology, 2009
- Treatment outcomes among patients with multidrug-resistant tuberculosis: systematic review and meta-analysisThe Lancet Infectious Diseases, 2009
- Performance of Purified Antigens for Serodiagnosis of Pulmonary Tuberculosis: a Meta-AnalysisClinical and Vaccine Immunology, 2009
- Long term efficacy of DOTS regimens for tuberculosis: systematic reviewBMJ, 2008
- Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysisInternational Journal of Epidemiology, 2008