Synaptic Proteins After Electroconvulsive Seizures in Immature Rats

Abstract

The forebrain content of several rat brain synaptic proteins (synaptin, D1, D2 and D3) was reduced in rats receiving electroconvulsive seizures on days 2-11, 9-18 or 19-28 and sacrificed at 30 days old. Forebrain weight, total protein and the glial enzyme glutamine synthetase were decreased; the neuronal enolase 14-3-2 was unchanged. Seizures in the immature rat brain apparently resulted in a parallel reduction of synaptic material and of the amount of glial cells. The increased concentration of the enolase 14-3-2 found in rats seizured on days 19-28 may reflect the high demands on the glycolytic system during the seizures.