Bone measurement by enhanced contrast image analysis: Ovariectomized and intact Macaca fascicularis as a model for human postmenopausal osteoporosis
- 1 June 1985
- journal article
- research article
- Published by Wiley in American Journal of Physical Anthropology
- Vol. 67 (2), 99-103
- https://doi.org/10.1002/ajpa.1330670204
Abstract
This paper presents an image enhancement and analysis system (DARWIN) based on an inexpensive microcomputer and applies the system to two bone morphometry problems relevant to postmenopausal osteoporosis. Using ovariectomized and intact female Macaca fascicularis as a model, we examined the radiodensity of the sixth lumbar vertebra and the cross‐section area of the right femur. Significantly lower bone density was observed in the vertebral segments of the ovariectomized animals. No significant differences were observed in comparisons of the femoral cross sections. The reduction in radiographic density of the ovariectomized animals' vertebrae is similar to that observed in postmenopausal women, supporting the use of female cynomolgus macaques as models of bone loss in postmenopausal osteoporosis.Keywords
This publication has 7 references indexed in Scilit:
- National Institutes of Health Consensus Development Conference. Consensus statement.Journal of Ultrasound in Medicine, 1984
- Mean wall thickness and formation periods of trabecular bone packets in corticosteroid-induced osteoporosisCalcified Tissue International, 1983
- Computer-Assisted Image Analysis of Tissues of Ethrel-Treated Pinus taeda SeedlingsPlant Physiology, 1983
- OsteoporosisJournal of the American Geriatrics Society, 1982
- Spinal Mineral Loss in Oophorectomized WomenPublished by American Medical Association (AMA) ,1980
- Histological Studies of Bone from Normocalcemic Postmenopausal Osteoporotic Patients with Increased Circulating Parathyroid HormoneJournal of Clinical Endocrinology & Metabolism, 1976
- Measurement of Bone Mineral in vivo: An Improved MethodScience, 1963