SOME POSTURAL ADJUSTMENTS OF SALT AND WATER EXCRETION 12
Open Access
- 1 August 1954
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 33 (8), 1089-1094
- https://doi.org/10.1172/jci102981
Abstract
In 6 normal human subjects undergoing moderate water diuresis quiet standing resulted in a slight depression of creatinine clearance and a marked depression of Na, Cl, K, and water excretion as compared with control measurements in the supine position. If the legs were wrapped with elastic bandages before the orthostatic position was assumed the depression of salt excretion was inhibited with varying effect on the antidiuresis. On the other hand, administration of alcohol inhibited the ortho-static antidiuresis and enhanced the orthostatic inhibition of salt excretion in 5 subjects. It is suggested that there are separate postural adjustments of water and salt excretion, the former under diencephalic posterior pituitary control and the latter under the control of some mechanism sensitive to the distribution of interstitial fluid.Keywords
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