A study of foot-and-mouth disease virus strains by complement fixation: I. A model for the fixation of complement by antigen/antibody mixtures
- 1 February 1974
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 72 (3), 397-405
- https://doi.org/10.1017/s0022172400023639
Abstract
SUMMARY An examination was made of the relations between antigen, antibody and fixation of complement with foot-and-mouth disease virus (FMDV). It was found that complement fixation in this system follows the same principles as models developed in other antigen/antibody systems. The assumption that there is a relation of direct proportionality between the amount of complement fixed and the amount of antiserum reacting with constant antigen was found to be incorrect. An alternative method was proposed for the quantitative differentiation of FMDV strains by comparing the titres of an antiserum when reacting with optimum amounts of homologous or heterologous antigens.Keywords
This publication has 12 references indexed in Scilit:
- A study of foot-and-mouth disease virus strains by complement fixation: II. A comparison of tube and microplate tests for the differentiation of strainsEpidemiology and Infection, 1974
- Comparative complement-fixation studies with subtype strains of foot-and-mouth disease virusEpidemiology and Infection, 1972
- A complement fixation technique for the quantitative measurement of antigenic differences between strains of the virus of foot-and-mouth diseaseEpidemiology and Infection, 1964
- Purification of Radioactive Foot-and-Mouth Disease VirusNature, 1963
- The Complement-Fixation Test in Studies of Components of the Virus System of Foot-and-Mouth Disease and its AntibodiesJournal of General Microbiology, 1960
- IMMUNOREACTIONS INVOLVING PLATELETSThe Journal of Experimental Medicine, 1958
- QUANTITATIVE STUDIES OF COMPLEMENT-FIXATION .5. ESTIMATION OF COMPLEMENT-FIXING POTENCY OF IMMUNE SERA AND ITS RELATION TO ANTIBODY-NITROGEN CONTENT1950
- The Serological Comparison of Strains of Influenza VirusJournal of General Microbiology, 1949
- Strains of Virus of Foot-and-Mouth Disease Recovered from Outbreaks in Mexico. Complement Fixation TestsExperimental Biology and Medicine, 1948
- Colloidal Chemistry and ImmunologyThe Journal of Infectious Diseases, 1916