Dose response in vivo to digoxin in normo- and hyperkalaemia: associated biochemical changes

Abstract

The effect of digoxin, at two different inotropic levels, was examined in normo- and hyperkalaemic dogs. For similar inotropic responses, normo- and hyperkalaemic dogs had similar levels of (Na⁺, K⁺)-ATPase inhibition and microsomal-bound digoxin.