Molecular mimicry and multiple sclerosis: Degenerate T-cell recognition and the induction of autoimmunity
- 1 May 1999
- journal article
- review article
- Published by Wiley in Annals of Neurology
- Vol. 45 (5), 559-567
- https://doi.org/10.1002/1531-8249(199905)45:5<559::aid-ana3>3.0.co;2-q
Abstract
Various mechanisms have been proposed for the initiation of autoimmune responses by autoreactive T‐cell clones. One of these, the molecular mimicry hypothesis, postulates that myelin‐reactive T‐cell clones are activated by foreign antigens. Until recently, sequence homology between self‐ and foreign antigens was considered necessary for cross‐recognition to occur in multiple sclerosis. This article reviews current progress in T‐cell receptor immunology that led to modify this view and proposes a role for degenerate T‐cell antigen recognition in the induction of autoimmunity. Ann Neurol 1999;45:559–567Keywords
This publication has 93 references indexed in Scilit:
- T CELL MEMORYAnnual Review of Immunology, 1998
- The Role of the Thymus in the Control of AutoimmunityJournal of Autoimmunity, 1996
- A differential-avidity model for T-cell selectionImmunology Today, 1994
- Negative selection of lymphocytesCell, 1994
- MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activationCell, 1994
- Positive selection of lymphocytesCell, 1994
- Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune responseCell, 1991
- Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic miceCell, 1991
- Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequencesHuman Immunology, 1989
- Multiple sclerosis☆Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different agesJournal of Neuroimmunology, 1983