Growth Hormone, Prolactin and Chorionic Somatomammotropin in Normal and Molar Pregnancy

Abstract

Twenty patients with molar pregnancy, ten normal pregnant women and ten healthy nonpregnant women were given 30 g of arginine intravenously. The serum concentration of growth hormone, prolactin and chorionic somatomammotropin (CS) was determined by radioimmunoassay. In addition, serum 17β-estradiol, estriol and progesterone were also measured. Arginine infusion induced a sharp rise of GH in patients with molar pregnancy and in nonpregnant subjects, but the response in normal pregnancy was blunted. The response of PRL was high in patients with molar pregnancy, blunted in normal pregnancy and very small in nonpregnant subjects. CS did not respond at all to arginine infusion both in normal pregnancy and molar pregnancy. The high response to arginine of PRL, normal response of GH and low baseline secretion and no response of CS may be characteristic of molar pregnancy.