Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease
- 1 August 1990
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 28 (2), 174-177
- https://doi.org/10.1002/ana.410280210
Abstract
Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.This publication has 14 references indexed in Scilit:
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