Lecithin: Cholesterol acyltransferase in liver disease
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 47 (6), 613-617
- https://doi.org/10.1080/00365518709168477
Abstract
Lecithin:cholesterol acyltransferase (LCAT) activity in patients with liver disease has been found to be either normal or lower than normal, but no information on LCAT mass in these patients is available. In this study, LCAT mass concentration together with LCAT activity and cholesterol esterification rate were measured in the plasma of 19 patients with cholestatic liver disease and 21 patients with non-cholestatic liver disease. The LCAT mass in plasma correlated positively with serum albumin (r = 0.69, p < 0.001) and pre-albumin (r = 0.77, p < 0.001) and negatively with serum bilirubin (r = -0.42, p < 0.01) and bile salts (r = -0.43, p < 0.01), thus reflecting the severity of liver disease and liver protein synthesizing capacity. In plasma, LCAT mass concentration also correlated well with LCAT activity (r = 0.88, p < 0.001) and cholesterol esterification rate (r = 0.73, p < 0.001), thereby indicating that the decrease of LCAT activity and cholesterol esterification rate in liver disese is primarily a function of decreased LCAT mass.This publication has 19 references indexed in Scilit:
- Factors that modify the flow response to intracoronary injections.Circulation, 1985
- Lipoprotein abnormalities in patients with early primary biliary cirrhosisEuropean Journal of Clinical Investigation, 1984
- Population-based reference values for lecithin-cholesterol acyltransferase (LCAT)Atherosclerosis, 1982
- Familial Lecithin‐Cholesterol Acyltransferase Deficiency in Four Norwegian FamiliesActa Medica Scandinavica, 1981
- Radioimmunoassay of human plasma lecithin-cholesterol acyltransferase.JCI Insight, 1981
- Secretion of lecithin:cholesterol acyltransferase from isolated rat hepatocytesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1976
- Lecithin: Cholesterol acyltransferase and plasma proteins in liver diseaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1974
- Metabolism of the Vitamin A Transporting Protein ComplexEuropean Journal of Clinical Investigation, 1973
- Plasma Lecithin: Cholesterol Acyltransferase Activity in Liver Disease*European Journal of Clinical Investigation, 1971
- PLASMA LECITHIN‐CHOLESTEROL ACYLTRANSFERASE AND ERYTHROCYTE LIPIDS IN LIVER DISEASEActa Medica Scandinavica, 1970