Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase
- 1 August 1978
- journal article
- specialia
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 34 (8), 1054-1055
- https://doi.org/10.1007/bf01915343
Abstract
Summary The inhibitory activity of 19 flavonoid molecules on cyclic AMP breakdown by a commercial beef heart phosphodiesterase preparation is reported. 7 compounds are active in the micromolar range, 2 of which have a potency equivalent to that of papaverine. Some structure activity relationships are drawn.This publication has 19 references indexed in Scilit:
- Selective inhibition of cyclic nucleotide phosphodiesterases by analogs of 1-methyl-3-isobutylxanthineBiochemistry, 1977
- Selective Cyclic Nucleotide Phosphodiesterase Inhibitors as Potential Therapeutic AgentsAnnual Review of Pharmacology and Toxicology, 1977
- Effect of flavone inhibitors of transport ATPases on histamine secretion from rat mast cellsNature, 1977
- Inhibition of (Na+ and K+)-dependent adenosine triphosphatase and its partial reactions by quercetinBiochemistry, 1976
- Pig heart mitochondrial ATPase : properties of purified and membrane-bound enzymeBiochimie, 1975
- Catechol O-methyltransferase. 5. Structure-activity relations for inhibition by flavonoidsJournal of Medicinal Chemistry, 1975
- Effects of quercetin and F1 inhibitor on mitochondrial ATPase and energy-linked reactions in submitochondrial particlesBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1974
- Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology, 1973
- Cyclic nucleotide phosphodiesterase inhibition and vascular smooth muscle relaxationEuropean Journal of Pharmacology, 1972
- Membrane formation in Tetrahymena pyriformis. 4. Lipid composition and biochemical properties of Tetrahymena pyriformis membrane systemsBiochemistry, 1971