Activated protein C resistance in normal pregnancy
- 1 September 1997
- journal article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 104 (9), 1084-1086
- https://doi.org/10.1111/j.1471-0528.1997.tb12072.x
Abstract
This prospective cross-sectional (10 women on each occasion) and longitudinal (20 women) study investigated activated protein C (APC) ratio in normal pregnancy. The APC ratio was measured at booking, 20, 30 and 36 weeks of gestation, and compared with a sample of normal nonpregnant women. No significant difference was found between APC ratios for pregnant women at any gestation and those of the nonpregnant population in either the longitudinal or cross-sectional studies. There was a significant decrease in APC ratios throughout pregnancy, but in all but one case values remained within the normal nonpregnant range. The APC ratio can therefore be used as a screening test for the factor V Leiden mutation during pregnancy.Keywords
This publication has 6 references indexed in Scilit:
- Resistance to activated protein C in an unselected population of patients with pulmonary embolismThe Lancet, 1996
- Are we ready for factor V Leiden screening?The Lancet, 1996
- Resistance to activated protein C as a basis for venous thromboembolism associated with pregnancy and oral contraceptivesAmerican Journal of Obstetrics and Gynecology, 1995
- Development of resistance to activated protein C during pregnancyBritish Journal of Haematology, 1995
- Mutation in blood coagulation factor V associated with resistance to activated protein CNature, 1994
- Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia StudyThe Lancet, 1993