Granulocytopoiesis

Abstract

IN consideration of the total picture of granulocytopoiesis one must consider each phase of a cell proliferation system that is in a steady-state equilibrium§ with fluxes superimposed upon the steady-state equilibrium by physiologic influxes into the blood and effluxes from the blood. The net result under conditions of health is a steady-state equilibrium. Although many schemes for granulocytopoiesis, showing the relation of the stem cell to proliferation and differentiation, have been drawn in the textbooks of hematology in the past it is necessary to consider the structure of each cytologic compartment as reported by Killmann et al.¹ in which a . . .