Further Observations on the Biosynthesis of Polyamines in Regenerating Rat Liver.

Abstract

Arginine is incorporated into liver polyamines, and this incorporation is increased during liver regeneration. Ornithine and putrescine or agmatine may be formed as intermediates. It was stated previously that we have indirect evidence that spermidine acts as a precursor in spermine synthesis. The incorporation of C14-spermidine into spermine was shown in regenerating rat liver.