Hemadsorption by Murine Tumors

Abstract

Tissue sections of methyl-cholanthrene(MC)-induced sarcomas as well as of some other murine tumors were shown to adsorb erythrocytes of human, guinea pig, and chicken origin. A similar hemadsorbing property could be demonstrated also in studying primary cell cultures of MC-sarcoma. Normal murine tissue, with the exception of spleen and lymph node, failed to hemadsorb. The hemadsorbing factor of MC-sarcoma sections was destroyed by moist heat at 56[degree]C, and by treatment with 95% ethanol, acetone, ether or 4% formalin. The attempts to obtain the factor in a saline-soluble form failed. Receptor destroying enzyme of Vibrio comma altered human erythrocytes so that they were not adsorbed by tissue sections or primary cell cultures of MC-sarcoma. The possibility that a virus-like agent is responsible for hemadsorption by MC-sarcoma is discussed.