Über den biologischen Ergänzungswert verschiedener Nahrungsproteine. V. Mitteilung. Pathologisch-anatomische Befunde bei cystinarm ernährten Ratten

Abstract

Histological studies made on 180 rats which had grown poorly and died on a diet deficient in cystine showed primary necrosis of the liver cells especially in the periphery of the lobes, thrombosis of the liver capillaries, and evidence of extensive bleeding and fatty degeneration of the capillary endo-thelium. The kidneys showed glomerulonephrosis. The changes corresponded to those found in human eclampsia and indicated that severe disturbances in intermediary metabolism had occurred. Cystine and S-containing amino acids are probably needed for detoxification either of products formed by degradation of proteins and nucleo-proteins or of other toxic substances of metabolic origin.