Psoriasis and Raynaud's Phenomenon Associated with Autoantibodies to U1 and U2 Small Nuclear Ribonucleoproteins

Publisher Website
Google Scholar
Abstract
One of the hallmarks of systemic lupus erythematosus and related disorders is the production of antinuclear antibodies reactive with a variety of nuclear structures, including nucleic acids (DNA and RNA), proteins, and complexes of DNA or RNA with proteins.1 There has been particular interest in autoantibodies to ribonucleoproteins (complexes consisting of RNA noncovalently linked to protein). Detection of autoantibodies to specific types of ribonucleoproteins in patients' serum can be useful diagnostically,1 2 3 4 and serum samples containing such antibodies has been an important tool in molecular and cellular biology.5 6 7 8 The Sm antigen (named after the patient whose serum defined this reactivity)2 and . . .