Effect of dose fractionation on the ethylnitrosourea induction of specific-locus mutations in mouse spermatogonia.
- 1 June 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (11), 3592-3593
- https://doi.org/10.1073/pnas.79.11.3592
Abstract
As measured by specific-locus mutations in mouse spermatogonia, fractionating a dose of 100 mg ethylnitrosourea/kg of body weight into doses of 10 mg/kg injected i.p. at weekly intervals greatly reduces the mutation frequency compared with that from a single dose of 100 mg/kg. Because there is independent evidence that the doses of 10 and 100 mg/kg reach the germ cells in amounts directly proportional to the injected dose, the lower mutational response with the fractionated dose is attributed to repair. The induced mutation rate expected from a single 10-mg/kg dose (on the assumption that this would be 1/10th the rate observed after 10 such doses) would be only 75% of the spontaneous mutation rate. Mouse spermatogonia apparently have an efficient repair system that is effective even against a potent mutagen.This publication has 3 references indexed in Scilit:
- Dose--response curve for ethylnitrosourea-induced specific-locus mutations in mouse spermatogonia.Proceedings of the National Academy of Sciences, 1982
- Induction of gene mutations in germ cells of the mouseArchives of Toxicology, 1980
- X-RAY-INDUCED MUTATIONS IN MICECold Spring Harbor Symposia on Quantitative Biology, 1951