Transient shift of diacylglycerol and inositol lipids induced by interferon in Daudi cells
- 3 September 1990
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 269 (2), 465-468
- https://doi.org/10.1016/0014-5793(90)81216-b
Abstract
The effect of human recombinant DNA interferon-α type A on inositol lipid and diacylglycerol metabolism was investigated in Daudi lymphoma whole cells and isolated nuclei. In isolated nuclei after 90 min of interferon treatment an enhanced rate of PIP2 phosphorylation and an increase of DAG mass were observed. In whole cells, after 1 min of interferon treatment, there was a rapid and transient shift of DAG mass apparently not related to inositol lipid modifications, thus indicating the presence in nuclear and cytoplasmic compartments of inositol lipid fractions with different metabolic features in response to interferon-α.Keywords
This publication has 13 references indexed in Scilit:
- Early modifications of nucleic acid metabolism and nuclear lipid biosynthesis associated with antiproliferative activity of interferon-α on Daudi lymphoma cellsExperimental Cell Research, 1990
- Nuclear polyphosphoinositides during cell growth and differentiationAdvances in Enzyme Regulation, 1989
- Inositol phosphates and cell signallingNature, 1989
- Influence of phosphatidylcholine on two protein mRNA levels in interferon treated Daudi cellsCell Biology International Reports, 1989
- Changes in nuclear inositol phospholipids induced in intact cells by insulin-like growth factor IBiochemical and Biophysical Research Communications, 1989
- Lipid mediated signal transduction in the cell nucleusAdvances in Enzyme Regulation, 1988
- Rapid changes in phospholipid metabolism in the nuclei of Swiss 3T3 cells induced by treatment of the cells with insulin-like growth factor IBiochemical and Biophysical Research Communications, 1988
- Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiationBiochemical Journal, 1987
- Rapid and transient rise in diacylglycerol concentration in Daudi cells exposed to interferon.Proceedings of the National Academy of Sciences, 1986
- A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology, 1959