Maternal Obesity and Risk of Gestational Diabetes Mellitus
Top Cited Papers
Open Access
- 1 August 2007
- journal article
- research article
- Published by American Diabetes Association in Diabetes Care
- Vol. 30 (8), 2070-2076
- https://doi.org/10.2337/dc06-2559a
Abstract
OBJECTIVE—Numerous studies in the U.S. and elsewhere have reported an increased risk of gestational diabetes mellitus (GDM) among women who are overweight or obese compared with lean or normal-weight women. Despite the number and overall consistency of studies reporting a higher risk of GDM with increasing weight or BMI, the magnitude of the association remains uncertain. This meta-analysis was conducted to better estimate this risk and to explore differences across studies. RESEARCH DESIGN AND METHODS—We identified studies from three sources: 1) a PubMed search of relevant articles published between January 1980 and January 2006, 2) reference lists of publications selected from the PubMed search, and 3) reference lists of review articles on obesity and maternal outcomes published between January 2000 and January 2006. We used a Bayesian model to perform the meta-analysis and meta-regression. We included cohort-designed studies that reported obesity measures reflecting pregnancy body mass, that had a normal-weight comparison group, and that presented data allowing a quantitative measurement of risk. RESULTS—Twenty studies were included in the meta-analysis. The unadjusted ORs of developing GDM were 2.14 (95% CI 1.82–2.53), 3.56 (3.05–4.21), and 8.56 (5.07–16.04) among overweight, obese, and severely obese compared with normal-weight pregnant women, respectively. The meta-regression analysis found no evidence that these estimates were affected by selected study characteristics (publication date, study location, parity, type of data collection [retrospective vs. prospective], and prevalence of GDM among normal-weight women). CONCLUSIONS—Our findings indicate that high maternal weight is associated with a substantially higher risk of GDM.Keywords
This publication has 54 references indexed in Scilit:
- Missed Opportunities for Type 2 Diabetes Mellitus Screening Among Women With a History of Gestational Diabetes MellitusAmerican Journal of Public Health, 2006
- Postpartum Diabetes Screening in Women With a History of Gestational DiabetesObstetrics & Gynecology, 2005
- Maternal Outcomes in Pregnancies Complicated by ObesityObstetrics & Gynecology, 2005
- Glucose tolerance of 2- to 5-yr-old offspring of diabetic mothersPediatric Diabetes, 2004
- Meta-regression detected associations between heterogeneous treatment effects and study-level, but not patient-level, factorsJournal of Clinical Epidemiology, 2004
- An Increase in the Incidence of Gestational Diabetes Mellitus: Northern California, 1991–2000Obstetrics & Gynecology, 2004
- Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetesDiabetic Medicine, 2004
- Failure to obtain follow-up testing for gestational diabetic patients in a rural population*1Obstetrics & Gynecology, 1999
- Pregnancy Outcome and Weight Gain Recommendations for the Morbidly Obese WomanObstetrics & Gynecology, 1998
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986