Histamine release by pharmacological agents in the absence of external free Ca2+
- 17 September 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 175 (1), 147-151
- https://doi.org/10.1016/0014-5793(84)80588-8
Abstract
The involvement of extracellular free Ca2+ in histamine release was investigated in rat peritoneal mast cells. Incubation of non-antigenized cells in a media with high extracellular potassium did not increase histamine release. Secretion induced by A23187 and compound in the presence of Ca2+ requires metabolic energy. In the absence of external free Ca2+ (2.5 μM) histamine release induced by A23187 is reduced but not abolished. Secretion induced by compound is independent of extracellular Ca2+. These results lead us to suggest that mast cell plasma membranes probably lack voltage-gated Ca2+ channels and that external Ca2+ may not be an absolute requisite for histamine secretion.
Keywords
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