Taurine Pool Sizes in the Rat: Effects of Vitamin B-6 Deficiency and High Taurine Diet
- 1 November 1973
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 103 (11), 1566-1580
- https://doi.org/10.1093/jn/103.11.1566
Abstract
The specific activity of taurine was measured in a number of tissues and body fluids of the rat at various times after injection of 35S-taurine. The results provide evidence of separate taurine pools with different characteristics, and estimates of the sizes and half-lives of these pools. The results suggest that a 150 g rat has a rapidly miscible taurine pool of approximately 1.0 mmole with a half-life of 3 days and another, slowly miscible, pool of approximately 1.5 mmoles with a half-life of 24 days. Feeding a vitamin B-6-deficient diet resulted in a markedly decreased excretion of taurine in urine and feces, but not in a decreased total taurine content of the body. The distribution between the pools was changed to approximately 0.5 mmole with no change in half-life and approximately 2.0 mmoles with a manyfold increase in half-life. Supplementing either diet with taurine had little effect on the concentration of taurine in the various tissues, with the exception of liver and plasma, and the extra taurine consumed was recovered almost quantitatively in the urine and feces. Supplementation did have a considerable effect on the kinetics of elimination of the 35S-taurine, especially in animals fed the vitamin B-6-deficient diet, where the half-life of the slowly miscible taurine pool was reduced to the same order of magnitude as that of the control animals. Supplementing the control diet with taurine caused a reduction in the half-life of the rapidly miscible pool.Keywords
This publication has 37 references indexed in Scilit:
- Long-Term Kinetics of Serum and Xanthoma Cholesterol Radioactivity in Patients with HypercholesterolemiaJCI Insight, 1972
- Cystine metabolism in vitamin B6 deficiency: Evidence of muliple taurine poolsBiochemical Medicine, 1971
- Absence of Cystathionase in Human Fetal Liver: Is Cystine Essential?Science, 1970
- Metabolism of l-35S-methionine in vitamin B6 deficiency: Observations on cystathioninuriaBiochemical Medicine, 1970
- Effects of deficiency of vitamin B6 on transsulfurationBiochemical Medicine, 1969
- Distribution of Radioactivity after Administration of Taurine-35S in RatsCHEMICAL & PHARMACEUTICAL BULLETIN, 1969
- THE EFFECT OF A NUTRITIONAL PYRIDOXINE DEFICIENCY ON FREE AMINO ACIDS AND RELATED SUBSTANCES IN MOUSE BRAIN*Journal of Neurochemistry, 1967
- Turbidimetric Analysis of Inorganic Sulfate in Serum, Plasma and UrineScandinavian Journal of Clinical and Laboratory Investigation, 1960
- Etude du métabolisme de la taurine chez le rat. Formation de sulfateBiochimica et Biophysica Acta, 1957
- Répercussion d'une carence en vitamine B6 sur le métabolisme de l'acide L-cystéinesulfinique, in vitro et in vivo, chez le ratBiochimica et Biophysica Acta, 1954