Studies of IFN-Induced Transcriptional Activation Uncover the Jak-Stat Pathway
- 1 August 1998
- journal article
- review article
- Published by Mary Ann Liebert Inc in Journal of Interferon & Cytokine Research
- Vol. 18 (8), 549-554
- https://doi.org/10.1089/jir.1998.18.549
Abstract
Sharing the Milstein Award with George R. Stark and Ian M. Kerr in the fall of 1997 brought this invitation to record personal reflections on our experiments concerning the mechanisms of action of interferon. Our work and that of the Kerr and Stark laboratories uncovered the Jak-Stat pathway through which signals from cell surface receptors reach genes in the cell nucleus. This review concentrates on that to which I can speak most reliably, that is, experiments done by my young colleagues at Rockefeller University.Keywords
This publication has 62 references indexed in Scilit:
- STATs and Gene RegulationScience, 1997
- TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT PathwayAnnual Review of Biochemistry, 1995
- A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.Genes & Development, 1995
- Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6Science, 1994
- Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathwayCell, 1994
- Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription FactorScience, 1992
- A protein tyrosine kinase in the interferon αβ signaling pathwayCell, 1992
- Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liverJournal of Molecular Biology, 1984
- Globin RNA transcription: A possible termination site and demonstration of transcriptional control correlated with altered chromatin structureCell, 1982
- Interferon-sepharose: Induction of the antiviral stateBiochemical and Biophysical Research Communications, 1974