Graded Reduction of Arterial Pressure in Man by Means of a Thiophanium Derivative (Ro 2-2222)

Abstract

The authors describe the use of a ganglionic blocking agent which acts almost entirely as a peripheral vasodilator with minimal side effects in man. This substance acts almost instantaneously when given intravenously, with the depressor effect quantitatively controlled by regulating the infusion rate without tachyphylaxis over several hours. Depressor effect of the drug disappears 2 to 15 minutes after stopping the infusion and is blocked promptly by intravenous ephedrine, neosynephrine or norepinephrine. The authors discuss its use in the treatment and elucidation of the basic mechanisms of acute pulmonary edema.