INDIVIDUAL ANTIGENIC SPECIFICITY OF MYELOMA PROTEINS
Open Access
- 1 April 1965
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 121 (4), 561-575
- https://doi.org/10.1084/jem.121.4.561
Abstract
The specific antigenic structure of individual myeloma proteins was investigated for the presence of similar antigenic determinants in pooled γ-globulin and for the localization of these determinants on the γ-globulin molecules. Quantitative precipitin analyses demonstrated that in most instances absorption of antisera specific for an individual myeloma protein with large amounts of γ-globulin markedly reduced or completely removed the reactivity of the antiserum for the homologous myeloma protein. In only one instance did strong specificity remain after absorption with 100 mg of Fr II per cc of antiserum.Keywords
This publication has 23 references indexed in Scilit:
- Subclasses of Human γ 2 -Globulin Based on Differences in the Heavy Polypeptide ChainsScience, 1964
- The Subunits of Purified Rabbit Antibody*Biochemistry, 1964
- SPECIFIC COMBINATION OF H AND L CHAINS OF RABBIT γ-GLOBULINSProceedings of the National Academy of Sciences, 1964
- Individual and Sub-Group Antigenic Specificity of Bence-Jones ProteinNature, 1963
- Individual Antigenic Specificity of Isolated AntibodiesScience, 1963
- CLASSIFICATION OF MYELOMA PROTEINS, BENCE JONES PROTEINS, AND MACROGLOBULINS INTO TWO GROUPS ON THE BASIS OF COMMON ANTIGENIC CHARACTERSThe Journal of Experimental Medicine, 1962
- REDUCTION OF GAMMA-GLOBULINS1962
- The hydrolysis of rabbit γ-globulin and antibodies with crystalline papainBiochemical Journal, 1959
- ANTIGENIC IDENTITY OF HYPERGLOBULINEMIC SERUM COMPONENTS WITH PROTEINS OF NORMAL SERUMJournal of Biological Chemistry, 1956
- Zone ElectrophoresisPublished by Wiley ,1954