The Metabolism of the Local Anaesthetic Fomocaine (1-Morpholino-3-[p-phenoxymethylpheny1]propane) in the Rat and Dog after Oral Application
- 1 January 1975
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 5 (5), 309-323
- https://doi.org/10.3109/00498257509052065
Abstract
1. The metabolism of fomocaine following its oral administration to male and female Wistar rats and male beagle dogs has been qualitatively investigated. 2. The drug is metabolized in both species by aromatic hydroxylation, N-oxidation, splitting of the ether link and, in the dog, by removal of the morpholine group. 3. The rat and dog excrete some unchanged fomocaine in the urine together with p-hydroxyfomocaine (free and conjugated), fomocaine-N-oxide, p-hydroxy-fomocaine-N-oxide and p-(γ-morpholinopropyl)benzoic acid. In addition, the dog excretes morpholine in the urine.Keywords
This publication has 3 references indexed in Scilit:
- Thin-layer chromatography of chlorpromazine metabolites : Attempt to identify each of the metabolites appearing in blood, urine and feces of chronically medicated schizophrenicsJournal of Chromatography A, 1973
- A note on the identification of N-hydroxyphenmetrazine as a metabolic product of phendimetrazine and phenmetrazineJournal of Pharmacy and Pharmacology, 1972
- Titanometric Determination of N-Oxide Group in Pyridine-N-Oxide and Related CompoundsAnalytical Chemistry, 1959