INTRACELLULAR SIGNALING FROM THE ENDOPLASMIC RETICULUM TO THE NUCLEUS
- 1 November 1998
- journal article
- review article
- Published by Annual Reviews in Annual Review of Cell and Developmental Biology
- Vol. 14 (1), 459-485
- https://doi.org/10.1146/annurev.cellbio.14.1.459
Abstract
▪ Abstract Cells respond to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing transcription of genes encoding ER resident proteins. The information is transmitted from the ER lumen to the nucleus by an intracellular signaling pathway called the unfolded protein response (UPR). Recent work has shown that this signaling pathway utilizes several novel mechanisms, including translational attenuation and a regulated mRNA splicing step. In this review we aim to integrate these recent advances with current knowledge about maintenance of ER composition and abundance.Keywords
This publication has 76 references indexed in Scilit:
- tRNA Ligase Is Required for Regulated mRNA Splicing in the Unfolded Protein ResponseCell, 1996
- A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein ResponseCell, 1996
- The 170 kDa glucose regulated stress protein is a large HSP70‐ HSP110‐like protein of the endoplasmic reticulumFEBS Letters, 1996
- Regulation of Organelle BiogenesisCell, 1996
- Insights from inducible membranesCurrent Biology, 1993
- A hybrid protein kinase‐RNase in an interferon‐induced pathway?FEBS Letters, 1993
- A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleusCell, 1993
- Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseCell, 1993
- Molecular cloning and characterization of the primary structure of the alkane hydroxylating cytochrome P-450 from the yeast Candida maltosaBiochemical and Biophysical Research Communications, 1989
- Quantitative analysis of smooth and rough endoplasmic reticulum proliferation in differentiating hepatocytes of midpostnatal mice treated with phenobarbitalJournal of Ultrastructure and Molecular Structure Research, 1986