Cephalomannine; a new antitumour alkaloid from Cephalotaxus mannii

Abstract

Chemical investigation of the antileukaemic and cytotoxic principles of Cephalotaxus mannii has led to the isolation and characterization of cephalomannine, an alkaloidal taxane derivative structurally unrelated to the harringtonine series of alkaloids characteristic of most Cephalotaxus species.