Environmental Stimulation Reduces Learning Deficits in Experimental Cretinism
- 13 February 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 191 (4227), 578-579
- https://doi.org/10.1126/science.943127
Abstract
Behavioral deficits in adult rats exposed perinatally to thiouracil were substantially reduced or elimated by a 5-week period of "superenriched" postweaning rearing conditions before testing. This treatment resulted in remediation of hypothyroid rats' deficits in maze learning, maze retention, and resistance to extinction of bar-pressing; the facilitative effect persisted for more than 4 months. These behavioral results were consistent with neurohistological findings from studies of early thyroid deficiency and postweaning environmental stimulation in rats.This publication has 16 references indexed in Scilit:
- Severity and timing of early thyroid deficiency as factors in the induction of learning disorders in ratsHormones and Behavior, 1976
- Perinatal hypothyroidism in rats: Persistent motivational and metabolic effectsDevelopmental Psychobiology, 1976
- Effects of successive environments on brain measuresPhysiology & Behavior, 1974
- Effects of differential experience on dendritic spine counts in rat cerebral cortex.Journal of Comparative and Physiological Psychology, 1973
- Remediating maze deficiencies by the use of environmental enrichment.Developmental Psychology, 1972
- Hypothyroidism: Learning deficit induced in rats by early exposure to thiouracil*1Hormones and Behavior, 1972
- Synaptogenesis in the Rat Cerebellum: Effects of Early Hypo- and HyperthyroidismScience, 1972
- Nutritional and Environmental Interactions in the Behavioral Development of the Rat: Long-Term EffectsScience, 1972
- Cretinism in Rats: Enduring Behavioral Deficit Induced by TricyanoaminopropeneScience, 1970
- Dorsal and ventral hippocampus lesions and maze learning: Influence of preoperative environment.Canadian Journal of Psychology / Revue canadienne de psychologie, 1965