Heterogeneity of D2 dopamine receptors in different brain regions
- 1 December 1987
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 248 (2), 595-602
- https://doi.org/10.1042/bj2480595
Abstract
The binding of [3H]spiperone has been examined in membranes derived from different regions of bovine brain. In caudate nucleus, nucleus accumbens, olfactory tubercle and putamen binding is to D2 dopamine and 5HT2 serotonin receptors, whereas in cingulate cortex only serotonin 5HT2 receptor binding can be detected. D2 dopamine receptors were examined in detail in caudate nucleus, olfactory tubercle and putamen using [3H]spiperone binding in the presence of 0.3 microM-mianserin (to block 5HT2 serotonin receptors). No evidence for heterogeneity among D2 dopamine receptors either between brain regions or within a brain region was found from the displacements of [3H]spiperone binding by a range of antagonists, including dibenzazepines and substituted benzamides. Regulation of agonist binding by guanine nucleotides did, however, differ between regions. In caudate nucleus a population of agonist binding sites appeared resistant to guanine nucleotide regulation, whereas this was not the case in olfactory tubercle and putamen.This publication has 32 references indexed in Scilit:
- D-2 receptor stimulation inhibits cyclic AMP formation brought about by D-1 receptor stimulation in rat neostriatum but not nucleus accumbensEuropean Journal of Pharmacology, 1986
- D2Dopamine Receptors in Calf Globus Pallidus: Agonist High- and Low-Affinity Sites Not Regulated by Guanine NucleotideJournal of Neurochemistry, 1985
- Complete Conversion of Brain D2 Dopamine Receptors from the High‐ to the Low‐Affinity State for Dopamine Agonists, Using Sodium Ions and Guanine NucleotideJournal of Neurochemistry, 1985
- Widespread Distribution of Brain Dopamine Receptors Evidenced with [ 125 I]Iodosulpride, a Highly Selective LigandScience, 1985
- Dopamine D2Receptors in the Anterior Pituitary: A Single Population Without Reciprocal Antagonist/Agonist StatesJournal of Neurochemistry, 1985
- Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine NeuronsScience, 1983
- THIORIDAZINE IS NOT SPECIFIC FOR LIMBIC DOPAMINE RECEPTORSThe Lancet, 1982
- Selective labelling of dopamine (D2) receptors in rat striatum by [3H]domperidone but not by [3H]spiperoneEuropean Journal of Pharmacology, 1982
- Use of [3H] Spiperone for Labelling Dopaminergic and Serotonergic Receptors in Bovine Caudate NucleusJournal of Neurochemistry, 1981
- Neuroleptic antagonism of dyskinetic phenomenaEuropean Journal of Pharmacology, 1975