Hemoglobin Solution-from Tetramer to Polymer
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Biomaterials, Artificial Cells and Artificial Organs
- Vol. 16 (1-3), 57-69
- https://doi.org/10.3109/10731198809132555
Abstract
Efforts to produce a clinically acceptable hemoglobin solution that could function as a temporary oxygen carrier have evolved through several stages. Beginning with the simple tetramer, we have lowered the affinity state by pyridoxylation and then polymerized the modified tetramer. This new substance, polyhemoglobin, has a normal oxygen capacity and a half-life of 38 hours. Issues of nephrotoxicity and immunocompetence after infusion remain to be defined.Keywords
This publication has 13 references indexed in Scilit:
- Preparation and in vitro characteristics of polymerized pyridoxylated hemoglobinTransfusion, 1983
- Hemoglobin solution: Is a normal [Hb] or P50 more important?Journal of Surgical Research, 1982
- Large-volume preparation of pyridoxylated hemoglobin with high P50Journal of Surgical Research, 1981
- Stromafree haemoglobin solution as a blood replacement fluid actual state and problemsIntensive Care Medicine, 1975
- Acute Changes in Oxyhemoglobin Affinity EFFECTS ON OXYGEN TRANSPORT AND UTILIZATIONJCI Insight, 1973
- Affinity labeling of the polyphosphate binding site of hemoglobinBiochemistry, 1972
- Effects of red cell stroma-free hemoglobin solution on renal function in monkeysJournal of Applied Physiology, 1970
- The Role of Intravascular Haemolysis and the Reticulo-Endothelial System in the Production of a Hypercoagulable StateBritish Journal of Haematology, 1968
- EVALUATION OF A STROMA-FREE HEMOGLOBIN SOLUTION FOR USE AS A PLASMA EXPANDERThe Journal of Experimental Medicine, 1967
- Oxygen consumption with hemoglobin‐ringerJournal of Cellular and Comparative Physiology, 1934