VEGF receptor Flk‐1 plays an important role in c‐kit expression in adipose tissue derived stem cells
- 5 September 2007
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (24), 4681-4684
- https://doi.org/10.1016/j.febslet.2007.08.063
Abstract
It is known that c-kit+ cells are increased in heart after infarction. The exact origins of the cardiac c-kit+ cells remain to be determined. We asked whether adipose tissue could be a potential source of c-kit+ cells. Our data show that the number of c-kit+ cells increased in adipose tissue derived stem cells when cultured with conditioned medium from neonatal cardiomyocytes grown under serum deprivation and hypoxia condition. We also found that VEGF receptor Flk-1 is involved in c-kit up regulation via ERK-mediated pathwayKeywords
This publication has 17 references indexed in Scilit:
- Rosiglitazone promotes development of a novel adipocyte population from bone marrow–derived circulating progenitor cellsJCI Insight, 2006
- Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokinesJCI Insight, 2006
- Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarctionNature Medicine, 2006
- Novel Autologous Cell Therapy in Ischemic Limb Disease Through Growth Factor Secretion by Cultured Adipose Tissue–Derived Stromal CellsArteriosclerosis, Thrombosis, and Vascular Biology, 2005
- Improvement of Postnatal Neovascularization by Human Adipose Tissue-Derived Stem CellsCirculation, 2004
- Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal CellsCirculation, 2004
- Plasticity of Human Adipose Lineage Cells Toward Endothelial CellsCirculation, 2004
- Adult Cardiac Stem Cells Are Multipotent and Support Myocardial RegenerationCell, 2003
- Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based TherapiesTissue Engineering, 2001
- Mesenchymal stem cellsJournal of Orthopaedic Research, 1991