HBZ interacts with JunD and stimulates its transcriptional activity
- 4 March 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 562 (1-3), 165-170
- https://doi.org/10.1016/s0014-5793(04)00225-x
Abstract
Human T-cell leukemia virus type I (HTLV-I) bZIP factor (HBZ) is a viral basic leucine zipper protein that was originally described as a partner of cAMP response element binding protein-2 and as a repressor of HTLV-I viral transcription. In addition, HBZ is able to interact with the activator protein-1 (AP-1) transcription factors c-Jun and JunB, the interaction with c-Jun leading to a transcriptional repression of AP-1-regulated genes. Here we show that HBZ also interacts with JunD in vitro and in vivo, and that this association occurs via the bZIP domain of the two proteins. Moreover, we show that HBZ can activate JunD-dependent transcription and that its amino-terminus is required.Keywords
This publication has 23 references indexed in Scilit:
- The HBZ Factor of Human T-cell Leukemia Virus Type I Dimerizes with Transcription Factors JunB and c-Jun and Modulates Their Transcriptional ActivityJournal of Biological Chemistry, 2003
- The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral TranscriptionJournal of Virology, 2002
- AP-1 in cell proliferation and survivalOncogene, 2001
- Human T-Cell Leukemia Virus Type 1 Tax Protein Activates Transcription through AP-1 Site by Inducing DNA Binding Activity in T CellsVirology, 2001
- Molecular Cloning of a Novel Human I-mfa Domain-containing Protein That Differently Regulates Human T-cell Leukemia Virus Type I and HIV-1 ExpressionPublished by Elsevier ,2000
- Multiple Control Levels of Cell Proliferation by Human T-Cell Leukemia Virus Type 1 Tax ProteinVirology, 1999
- AP-1 function and regulationCurrent Opinion in Cell Biology, 1997
- Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes.Genes & Development, 1992
- HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α GeneScience, 1988
- The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding ProteinsScience, 1988