The regulation of the cholesterol biosynthetic pathway has received much attention because of its close relation to the cellular synthesis of polyisoprenoids. The genes of the cascade of enzymes involved in the pathway are receiving intense study. Investigations on the development of inhibitors of the pathway are continuing because of possibilities of controlling hypercholesterolemia. This review highlights some aspects of the progress during the past year in understanding the regulation of expression of the genes of the pathway as well as post-transcriptional factors and inhibitors affecting cellular cholesterol homeostasis.