Influence of Amino-Acids on Adrenal Enlargement, Nephrosclerosis and Hypertension by Anterior Pituitary Preparations.

Abstract

Adrenal enlargement, nephrosclerosis and hypertension were produced by a lyophilized anterior pituitary (LAP) prepn. in rats kept on a synthetic diet containing no protein, but an adequate amt. of amino-acids. The severity of the lesions was less marked, however, than in rats receiving an equivalent amt. of N in the form of a casein-hydrolysate. It appears that amino-acids suffice to sensitize the organism to the production of hypertensive disease by LAP. This is noteworthy since no such pathologic changes can be produced by LAP on other diets deficient in proteins.