γ‐Tocopherol Induces Apoptosis in Androgen‐Responsive LNCaP Prostate Cancer Cells via Caspase‐Dependent and Independent Mechanisms
- 1 December 2004
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1031 (1), 399-400
- https://doi.org/10.1196/annals.1331.056
Abstract
Abstract: We found that γ‐tocopherol, the predominant vitamin E form in diets, but not α‐tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC‐3, LNCaP) and lung (A549) cancer cells. γ‐Tocopherol induced apoptosis in androgen‐sensitive LNCaP but not androgen‐resistant PC‐3 cells. Consequently, γ‐tocopherol treatment caused cytochrome c release and caspase‐9, ‐3 and ‐7 activation. However, the apoptosis could not be completely reversed by an irreversible pancaspase inhibitor, indicating that an alternative caspase‐independent pathway may also be involved. Our study suggests that γ‐tocopherol may be valuable in the prevention and therapy for certain types of cancer.This publication has 6 references indexed in Scilit:
- γ‐Tocopherol, but not α‐tocopherol, decreases proinflammatory eicosanoids and inflammation damage in ratsThe FASEB Journal, 2003
- γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attentionThe American Journal of Clinical Nutrition, 2001
- Five‐lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactionsThe FASEB Journal, 2001
- Cyclooxygenases and lipoxygenases as potential targets for treatment of pancreatic cancerPancreatology, 2001
- Association Between alpha-Tocopherol, gamma-Tocopherol, Selenium, and Subsequent Prostate CancerJNCI Journal of the National Cancer Institute, 2000
- γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cellsProceedings of the National Academy of Sciences, 2000