In Vitro Killing of Nosocomial Pathogens by Acid and Acidified Nitrite
- 1 November 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (11), 3901-3904
- https://doi.org/10.1128/aac.01506-05
Abstract
Exposure to pH 1 or 2 buffers or acidic gastric contents resulted in the killing of vancomycin-resistant Enterococcus sp., Klebsiella pneumoniae , Staphylococcus aureus , and Candida glabrata but not Clostridium difficile spores. Nitrite enhanced killing under acidic conditions, but significant killing of C. difficile spores required nitrite concentrations above usual physiological levels.Keywords
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