Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.
- 6 February 1996
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 93 (3), 1060-1064
- https://doi.org/10.1073/pnas.93.3.1060
Abstract
The heat shock protein Hsp90 is known as an essential component of several signal transduction pathways and has now been identified as an essential host factor for hepatitis B virus replication. Hsp90 interacts with the viral reverse transcriptase to facilitate the formation of a ribonucleoprotein (RNP) complex between the polymerase and an RNA ligand. This RNP complex is required early in replication for viral assembly and initiation of DNA synthesis through a protein-priming mechanism. These results thus invoke a role for the Hsp90 pathway in the formation of an RNP.Keywords
This publication has 18 references indexed in Scilit:
- The 23-kDa Acidic Protein in Reticulocyte Lysate Is the Weakly Bound Component of the hsp Foldosome That Is Required for Assembly of the Glucocorticoid Receptor into a Functional Heterocomplex with hsp90Journal of Biological Chemistry, 1995
- Hold 'em and Fold 'em: Chaperones and Signal TransductionScience, 1995
- Binding of p23 and hsp90 during assembly with the progesterone receptor.Molecular Endocrinology, 1995
- Distinct Roles of the Molecular Chaperone hsp90 in Modulating Dioxin Receptor Function via the Basic Helix-Loop-Helix and PAS DomainsMolecular and Cellular Biology, 1995
- Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.Proceedings of the National Academy of Sciences, 1994
- A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor.Molecular and Cellular Biology, 1994
- Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes.Molecular and Cellular Biology, 1994
- Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.Proceedings of the National Academy of Sciences, 1992
- Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcriptionNature, 1990
- Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNACell, 1986