Tcrb-V3+3T-cell deletion and a new mouse mammary tumor provirus,Mtv-44
- 1 January 1992
- journal article
- research article
- Published by Springer Nature in Immunogenetics
- Vol. 36 (3), 189-194
- https://doi.org/10.1007/bf00661096
Abstract
Genes encoding endogenous superantigens causing Tcrb-V3+ T-cell deletion co-segregate with mouse mammary tumor proviruses (Mtv),Mtv-3, Mtv-6, andMtv-13. In additionMtv-1 has been implicated in deletion of these T cells. We have examined levels of Tcrb-V3+ T cells andMtv integrations in the following off-spring and their parental strains, [(CBA-T6 × NZW)F1 × CBA], [(CBA × C3H/He)F1 × CBA], and [(B10.S (9R) × NOD]F1 mice. We show that a newMtv (Mtv-44) from NZW mice andMtv-1 from C3H/He mice cosegregate with genes encoding ligands for partial deletion of Tcrb-V3s+ T cells and that some NOD mice have an additionalMtv (Mtv-45) which is closely linked toMtv-3.Keywords
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