Epstein-Barr herpesvirus infection: Inhibition by immunologically induced mediators with interferon-like properties
- 15 July 1977
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 20 (1), 21-29
- https://doi.org/10.1002/ijc.2910200106
Abstract
When sensitized leukocytes were re-exposed to EBV antigen or to tuberculin-purified protein derivatives, they produced lymphokines, including the migration inhibition factor, which inhibited the migration of guinea-pig peritoneal exudate cells, and other lymphokines with the characteristics of interferon, which inhibited EBV-induced transformation and EBV superinfection of target cells. Unsensitized leucocytes from sero-negative adults and from neonates did not produce lymphokines when challenged with the antigens. This indicates that cell-mediated immunity and its associated soluble mediators may be involved in the control of EBV infection and that the interferon release assay is a useful in vitro correlate for the study of cellular immunity to EBV.This publication has 23 references indexed in Scilit:
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